Sign up for notifications from Insider! The population of unvaccinated adults is determined by subtracting the number of adults who received any dose of vaccine, as previously defined, from the population. The study did not adjust for maternal SARS-CoV-2 infections during pregnancy due to the inability of capturing home testing results. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Laurie M. Billing and Kenzie Teno report grants from the Council of State and Territorial Epidemiologists during the conduct of the study. In supplemental analyses by trimester of vaccination, receipt of the second dose during the second and third trimesters reduced the risk of infants testing SARS-CoV-2 positive during the Delta dominant period by 91% (95% CI: 63, 98) and 85% (95% CI: 50, 96), respectively, during the first 2 months of life, by 59% (95% CI: 21, 79) and 67% (95% CI: 37, 83) during the first 4 months of life and by 64% (95% CI:31, 81) and 53% (95% CI: 24, 71) during the first 6 months of life. Wkly. ***** An additional 172 (3.4%, 95% CI=2.7%4.2%) adults were partially vaccinated, 69 (0.9%, 95% CI=0.61.2) received a primary vaccination series <14 days before a positive for SARS-CoV-2 test result, and 186 (4.1%) had unknown vaccination status; these groups are not further described in this analysis. The average age of participants was 60.8 years, and 92.0% were White. Internet Explorer). CAS TN, NMF, SFlax, MC, DDA, AMP, and ST conceptualised the work. Vaccinated patients were older (68 vs. 57 years), and 62% had at least one comorbidity Admission to the ICU was 20%, and the mortality rate at 30 days was 14%. Pediatrics. The research was published yesterday in JAMA Internal Medicine. Vaccine 31, 21652168 (2013). Mothers were classified as either having had 2 doses or one dose of mRNA COVID-19 vaccines during pregnancy (and completed more than 14 days prior to delivery) or not having had any COVID-19 vaccines prior to delivery. Risk of hospital admission for patients with SARS-CoV-2 variant B.1.1.7: cohort analysis. Covid-19 vaccine effectiveness against the Omicron (B.1.1.529) variant. Defined as one or more of the following: chronic lung disease including asthma, chronic metabolic disease including diabetes mellitus, blood disorder/hemoglobinopathy, cardiovascular disease, neurologic disorder, immunocompromising condition, renal disease, gastrointestinal/liver disease, rheumatologic/autoimmune/inflammatory condition, obesity, feeding tube dependency, and wheelchair dependency. SARS-CoV-2 variant data update, England: Version 21. The proportion of hospitalized Black adults who received a primary COVID-19 vaccination series with or without a booster or additional dose increased from 4.7% and 14.9%, respectively, during the Delta-predominant period to 14.8% and 25.5%, respectively, during the Omicron-predominant period; Hispanic adults experienced smaller increases. Background: Risk stratification models have been developed to identify patients that are at a higher risk of COVID-19 infection and severe illness. Starting the week ending December 4, 2021, Maryland data are not included in weekly rate calculations but are included in previous weeks. During the Omicron-predominant period, weekly COVID-19associated hospitalization rates (hospitalizations per 100,000 adults) peaked at 38.4, compared with 15.5 during Delta predominance. Baden, L. R. et al. Kids' low COVID-19 vaccination rates called a 'gut punch' And in a second large study during the Omicron period, older people, men, and residents of nursing homes or in low-income areas were most at risk for post-booster COVID-19 death in England, but the risk was very low. A recent study found that the mean titer of maternally derived antibodies in infants of vaccinated mothers were higher at age 2 months compared with antibody titers at age 6 months23. Google Scholar. Acosta AM, Garg S, Pham H, et al. Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Rates are calculated using the CDC National Center for Health Statistics vintage 2020 bridged-race postcensal population estimates for the counties included in surveillance. ISSN 2041-1723 (online). Risk of reinfection, vaccine protection, and severity of infection with Monthly COVID-19 hospitalization rates were 3.5 to 17.7 times higher in unvaccinated patients than in their vaccinated counterparts, regardless of whether they had received a booster. It is possible that our exclusion criteria may have resulted in a final sample that may not be reflective of all KPNC infants. Author's reply, Efficacy, safety, and immunogenicity of the DNA SARS-CoV-2 vaccine (ZyCoV-D): the interim efficacy results of a phase 3, randomised, double-blind, placebo-controlled study in India, Centers for Disease Control and Prevention, MRC Biostatistics Unit COVID-19 Working Group, Cases, hospital admissions, and hospital attendances in those with delta and omicron SARS-CoV-2 variants, between Nov 29, 2021, and Jan 9, 2022, Risk of hospitalisation and mortality for COVID-19 cases with omicron compared with delta, overall and by age group, Estimated HRs for vaccination categories, secondary analysis. T.R. Pfizer and BioNTech Submit for U.S. Emergency Use Authorization of Vaccinated patients during the Delta wave were 37% (over with two doses), while during the Omicron wave they were 57%. U.S. regulators had authorized the Pfizer/BioNTech COVID-19 vaccine for children aged 5 to 11 years in October, prior to the Omicron surge. SARS-CoV-2 variants of concern and variants under investigation in England: technical briefing 35. If ethnicity was unknown, non-Hispanic ethnicity was assumed. Abbreviations: COVID-NET = COVID-19Associated Hospitalization Surveillance Network; ICU=intensive care unit; IMV=invasive mechanical ventilation; LTCF=long-term care facility; NA = not applicable. The rate among adults who received a primary series, but no booster or additional dose (133.5), was three times the rate among adults who received a booster or additional dose (45.0). Wkly Rep. 71, 352358 (2022). The company also said full results of its 2,250-person study confirmed the pill's promising early results against the virus: The drug reduced combined hospitalizations and deaths by about 89. In our primary analysis, we implemented a cohort study design where we used Cox proportional hazards models that allow for time-varying covariates to estimate the SARS-CoV-2 infection hazard ratio (HR) in infants of mothers vaccinated with at least 2 doses of mRNA COVID-19 vaccines during pregnancy and 1 dose only versus mothers who were unvaccinated during pregnancy. After the emergence of the Omicron variant, the rate of COVID-19 hospitalizations in the United States was 10.5 times higher in unvaccinated adults and 2.5 times higher in those who were vaccinated but received no booster than in booster recipients, according to a new study. During the study period, the omicron variant experienced a rapidly increasing incidence, whereas the delta variant was experiencing a decreasing or less rapidly increasing incidence. Individual and neighborhood factors associated with failure to vaccinate against influenza during pregnancy. Two to 4 weeks after a booster dose, vaccine effectiveness ranged from around 65-75%, dropped to 55-70% at 5 to 9 weeks, and 40-50% from 10 weeks or more after a booster dose. Lipkind, H. S. et al. 4% of cases) without NHS numbers were excluded from our primary analysis. Only 16% of children between the ages of 5 and 11 are fully vaccinated, and that number climbs to just over 50% of adolescents between ages 12 and 17, according to CDC data . Kids and Omicron: COVID Hospitalizations Soar Among NY Children - NBC Vaccination status (unvaccinated, receipt of a primary series only, or receipt of a primary series plus a booster or additional dose) was determined for individual hospitalized patients and for the catchment population using state immunization information systems data (2). As of December 25, the rate among unvaccinated people was 78 per 100,000, compared to 4 per 100,000 among fully vaccinated people, the CDC reported. 20, 15225 (2016). Sect. During the first 6 months of life, 940 (3.10%) infants tested positive for SARS-CoV-2 by polymerase chain reaction (PCR) test and 10 (0.03%) infants were hospitalized with a positive SARS-CoV-2 test. J. Fully-vaccinated in this chart meant one dose of the J&J vaccine or two doses of Pfizer or Moderna. Secondarily, we used a Test-Negative Design (TND), which is a case-control study, to compare the odds of vaccination among mothers of infants who tested positive vs. the odds of vaccination among mothers of infants who tested negative. J. Med. Implementing strategies that result in the equitable receipt of COVID-19 vaccinations, though building vaccine confidence, raising awareness of the benefits of vaccination, and removing barriers to vaccination access among persons with disproportionately higher hospitalizations rates from COVID-19, including Black adults, is an urgent public health priority. With wave after wave of SARS-CoV-2 variants, COVID-19 patients filled the worlds' hospitals and morgues because not everybody had access to vaccines or were willing to be vaccinated. Morb. The study was conducted among a cohort of infants born between December 15, 2020, and May 31, 2022. This conversion might result in character translation or format errors in the HTML version. We excluded these infants because we were primarily interested in estimating the effectiveness of mRNA vaccines received during pregnancy; (7) mothers who received adenovirus vector vaccines or any non-mRNA platform vaccines during pregnancy; (8) mothers who did not receive their mRNA vaccinations in accordance with CDC recommendationse.g., the timing between dose 1 and dose 2 was not within the recommended intervals; and (9) infants who did not become KPNC members within two calendar months of their birth. J. Med. Racial and ethnic disparities in rates of COVID-19associated hospitalization, intensive care unit admission, and in-hospital death in the United States from March 2020 to February 2021. 387, 227236 (2022). The group raised concerns about a small number of Guillain-Barre syndrome cases in vaccine recipients and wanted more data, especially on efficacy in those at highest risk. PubMed Central We further classified vaccination status by the trimester within which the second dose or the unique dose (for those who received only one dose) was received. The efficacy of COVID 19 vaccines for reducing the risk of severe COVID-19 infection is demonstrated in real life. Slider with three articles shown per slide. PubMed Like influenza and Tdap vaccines15,16, data suggest that vaccination during pregnancy may protect infants who are not old enough to be vaccinated against COVID-19. Frequency, characteristics and complications of COVID-19 in hospitalized infants. There were only one hospitalized case among the children of vaccinated mothers and nine hospitalized cases among the children of unvaccinated mothers (Table1). Our primary cohort analysis used calendar days as the underlying scale to ensure that we compared infants of vaccinated and unvaccinated mothers on the same calendar days because vaccination status during pregnancy and risk of SARS-CoV-2 infection varied over the study period. Vaccinations were limited only to those received during pregnancy. J. National influenza and COVID-19 surveillance report: 27 January 2022 (week 4). Hospitalization rates and characteristics of children aged <18 years hospitalized with laboratory-confirmed COVID-19COVID-NET, 14 States, March 1-July 25, 2020. JAMA 326, 16291631 (2021). Infections are rare and can be severe or fatal, but so far scientists don't see genetic changes that pose an increased threat to people. Viruses | Free Full-Text | SARS-CoV-2 Seroprevalence among Canadian Article During the Delta dominant period, the crude incidences of testing positive for SARS-CoV-2 during the first 2, 4, and 6 months of life were lower among infants whose mothers received at least two doses of mRNA COVID-19 vaccines during pregnancy (0.75, 1.43, and 1.56 infants per 100 person-years [PY], respectively) than those whose mothers were not vaccinated during pregnancy (5.47, 5.10, and 4.78 infants per 100 PYs, respectively). We also conducted analyses based on the trimester during which the vaccine was received during pregnancy (first, second, or third trimester). Hospitalizations rates increased among all adults irrespective of vaccination status (unvaccinated, primary series only, or primary series plus a booster or additional dose). It is critical that nursing home residents stay up to date with CO VID-19 vaccines and receive a bivalent booster dose to maximize protection against COVID-19. Stock, Jade Carruthers, Rachael Wood, Joshua Guedalia, Michal Lipschuetz, Ofer Beharier, Tobias Homan, Sara Mazzilli, Domenico Martinelli, Manaf AlQahtani, Xing Du, Siddhartha Mukherjee, Jussipekka Salo, Milla Hgg, Lauri Sksvuori, Hiam Chemaitelly, Houssein H. Ayoub, Laith J. Abu-Raddad, Nature Communications Selected counties in California, Colorado, Connecticut, Georgia, Maryland, Michigan, Minnesota, New Mexico, New York, Ohio, Oregon, Tennessee, and Utah (https://www.cdc.gov/mmwr/volumes/69/wr/mm6915e3.htm). Data from the COVID-19Associated Hospitalization Surveillance Network (COVID-NET) were analyzed to compare COVID-19associated hospitalization rates among adults aged 18 years during B.1.617.2 (Delta; July 1December 18, 2021) and Omicron (December 19, 2021January 31, 2022) variant predominance, overall and by race/ethnicity and vaccination status. Article and statistical significance was assessed at two-sided p0.05. Adults who received booster doses were classified as those who completed the primary series and received an additional or booster dose on or after August 13, 2021, at any time after completion of the primary series, and 14 days before a positive test result for SARS-CoV-2, as COVID-19associated hospitalizations are a lagging indicator and time passed after receipt of a booster dose has been shown to be associated with reduced rates of COVID-19 infection (https://www.nejm.org/doi/full/10.1056/NEJMoa2114255). Models were adjusted for the covariates listed above. NEW YORK and MAINZ, GERMANY, March 1, 2023 Pfizer Inc. (NYSE: PFE) and BioNTech SE (Nasdaq: BNTX) today submitted an application to the U.S. Food and Drug Administration (FDA) for Emergency Use Authorization (EUA) of a booster (fourth) dose of the companies' Omicron BA.4/BA.5-adapted bivalent COVID-19 vaccine in children 6 months through 4 years of age (also referred to as under 5 years). Although both approaches adjusted for the same confounding factors, the effectiveness estimates from the TND were higher than those from the cohort design, which is consistent with our previous analyses of influenza vaccine effectiveness in which we also observed that the TND tended to result in higher vaccine effectiveness estimates than did our cohort analyses30. As with previous variants, being vaccinated greatly protects you from severe disease with omicron.